β2-adrenoceptors kick osteoarthritis – time to rethink prevention and therapy?
- Although, during the past decades, substantial advances emerged in identifying major local and systemic factors contributing to initiation and progression of osteoarthritis (OA), some neuroendocrine mechanisms are still not understood or even neglected when thinking about novel therapeutic options. One of which is the sympathetic nervous system that exhibits various OA-promoting effects in different tissues of the joint. Interestingly, the β2-adrenoceptor (AR) mediates the majority of these effects as demonstrated by several in vitro, in vivo as well as in clinical studies. This review article does not only summarize studies of the past two decades demonstrating that the β2-AR plays an OA-promoting role in different tissues of the joint but also aims to encourage the reader to think about next-level research to discover novel and innovative preventive and/or therapeutic strategies targeting the β2-AR in OA.
Download full text files
Additional Services
| Author: | Zsuzsa Jenei-LanzlORCiDGND, Rainer H. StraubORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-861102 |
| DOI: | https://doi.org/10.1016/j.joca.2024.06.012 |
| ISSN: | 1063-4584 |
| Parent Title (English): | Osteoarthritis and cartilage |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2024/06/28 |
| Date of first Publication: | 2024/06/28 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2024/07/02 |
| Tag: | adrenergic therapy; osteoarthritis; sympathetic nervous system; β2-adrenoceptor |
| Volume: | 2024 |
| Issue: | In Press, Journal Pre-proof |
| Page Number: | 24 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
