An inventory of lysosomal ABC transporters
- ABC transporters fulfill diverse physiological functions in different cellularlocalizations ranging from the plasma membrane to intracellular membranouscompartments. Several ABC transporters have been spotted in the endolyso-somal system, which consists of endosomes, autophagosomes, lysosomes, andlysosome-related organelles. In this review, we present an overview of lysoso-mal ABC transporters including ABCA2, ABCA3, ABCA5, ABCB6,ABCB9, and ABCD4, discussing their trafficking routes, putative substrates,potential physiological functions, and associated diseases. In addition, weoffer a critical evaluation of the literature linking ABC transporters to lyso-somal drug sequestration, examining pitfalls associated with in vitro modelsof drug resistance.
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| Author: | Gergely SzakacsORCiD, Rupert AbeleORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-614671 |
| DOI: | https://doi.org/10.1002/1873-3468.13967 |
| ISSN: | 1873-3468 |
| Parent Title (English): | FEBS letters : for the rapid publication of short reports in biochemistry, biophysics, and molecular biology |
| Publisher: | Wiley |
| Place of publication: | Chichester |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2020/10/24 |
| Date of first Publication: | 2020/10/24 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2021/07/21 |
| Tag: | ABC transporters; cholesterol; drug resistance; endolysosomal system; lipid; lysosomes; peptide transport; surfactant; trafficking; vitamin B12 |
| Volume: | 594.2020 |
| Issue: | 23 |
| Page Number: | 21 |
| First Page: | 3965 |
| Last Page: | 3985 |
| HeBIS-PPN: | 484658247 |
| Institutes: | Biochemie, Chemie und Pharmazie |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
