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RITA is expressed in trophoblastic cells and is involved in differentiation processes of the placenta

  • Preeclampsia (PE) remains a leading cause of maternal and perinatal mortality and morbidity worldwide. Its pathogenesis has not been fully elucidated and no causal therapy is currently available. It is of clinical relevance to decipher novel molecular biomarkers. RITA (RBP-J (recombination signal binding protein J)-interacting and tubulin-associated protein) has been identified as a negative modulator of the Notch pathway and as a microtubule-associated protein important for cell migration and invasion. In the present work, we have systematically studied RITA’s expression in primary placental tissues from patients with early- and late-onset PE as well as in various trophoblastic cell lines. RITA is expressed in primary placental tissues throughout gestation, especially in proliferative villous cytotrophoblasts, in the terminally differentiated syncytiotrophoblast, and in migrating extravillous trophoblasts. RITA’s messenger RNA (mRNA) level is decreased in primary tissue samples from early-onset PE patients. The deficiency of RITA impairs the motility and invasion capacity of trophoblastic cell lines, and compromises the fusion ability of trophoblast-derived choriocarcinoma cells. These data suggest that RITA may play important roles in the development of the placenta and possibly in the pathogenesis of PE.

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Author:Julia Maria Wildner, Alexandra Friemel, Lukas JenneweinORCiDGND, Susanne Roth, Andreas Hans RitterORCiDGND, Cornelia Schüttler, Qi Chen, Frank LouwenORCiDGND, Juping YuanORCiDGND, Nina-Naomi KreisORCiDGND
URN:urn:nbn:de:hebis:30:3-516561
DOI:https://doi.org/10.3390/cells8121484
ISSN:2073-4409
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/31766533
Parent Title (English):Cells
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/11/21
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/02/03
Tag:RITA; fusion; invasion; motility; preeclampsia; trophoblasts
Volume:8
Issue:12, Art. 1484
Page Number:18
First Page:1
Last Page:18
Note:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
HeBIS-PPN:460950770
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 4.0