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Calcipotriol/betamethasone dipropionate aerosol foam for the treatment of psoriasis vulgaris : case series and review of the literature

  • An aerosol foam formulation of a once-daily, fixed-dose combination of a synthetic vitamin D3 analog/synthetic corticosteroid (calcipotriol [Cal] 50 µg/g and betamethasone dipropionate [BD] 0.5 mg/g) has recently been introduced for the topical treatment of plaque psoriasis in adults. Data from several sources – randomized controlled trials, case reports (as highlighted in this review), and real-world evidence (RWE) – underscore the considerable and rapid clinical response, effectiveness, and favorable safety and tolerability of Cal/BD aerosol foam in mild-to-moderate psoriatic patients previously treated with class 3 or 4 topical corticosteroids, in patients unsatisfied with ongoing phototherapy in combination with topical therapy and in patients with moderate-to-severe psoriasis. In addition, our case series, considered together with other RWE, highlights that Cal/BD aerosol foam is more effective and with greater levels of patient preference and acceptability than comparator preparations. Thus, Cal/BD aerosol foam offers several treatment advantages, including relief of itch, and is an appropriate first-line topical therapy for consideration in patients with psoriasis of any severity.
Metadaten
Author:Andreas PinterORCiDGND, Henrik Thormann, Flavia Angeletti, Ahmad Jalili
URN:urn:nbn:de:hebis:30:3-477339
DOI:https://doi.org/10.2147/CCID.S180698
ISSN:1178-7015
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30349342
Parent Title (English):Clinical, cosmetic and investigational dermatology
Publisher:Dove Medical Press
Place of publication:Albany, Auckland
Contributor(s):Jeffrey Weinberg, Amy Norman
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/10/09
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/10/25
Tag:aerosol; betamethasone dipropionate; calcipotriol; psoriasis
Volume:11
Page Number:9
First Page:451
Last Page:459
Note:
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
HeBIS-PPN:439188555
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell 3.0