Impact of liver fibrosis on survival of patients with intrahepatic cholangiocarcinoma receiving gemcitabine-based chemotherapy
- Intrahepatic cholangiocarcinoma (iCCA) is the most frequent subtype of cholangiocarcinoma (CCA), and the incidence has globally increased in recent years. In contrast to surgically treated iCCA, data on the impact of fibrosis on survival in patients undergoing palliative chemotherapy are missing. We retrospectively analyzed the cases of 70 patients diagnosed with iCCA between 2007 and 2020 in our tertiary hospital. Histopathological assessment of fibrosis was performed by an expert hepatobiliary pathologist. Additionally, the fibrosis-4 score (FIB-4) was calculated as a non-invasive surrogate marker for liver fibrosis. For overall survival (OS) and progression-free survival (PFS), Kaplan–Meier curves and Cox-regression analyses were performed. Subgroup analyses revealed a median OS of 21 months (95% CI = 16.7–25.2 months) and 16 months (95% CI = 7.6–24.4 months) for low and high fibrosis, respectively (p = 0.152). In non-cirrhotic patients, the median OS was 21.8 months (95% CI = 17.1–26.4 months), compared with 9.5 months (95% CI = 4.6–14.3 months) in cirrhotic patients (p = 0.007). In conclusion, patients with iCCA and cirrhosis receiving palliative chemotherapy have decreased OS rates, while fibrosis has no significant impact on OS or PFS. These patients should not be prevented from state-of-the-art first-line chemotherapy.
Author: | Maximilian Nikolai KinzlerORCiDGND, Christina KlasenGND, Falko SchulzeGND, Eva HerrmannORCiDGND, Andreas SchnitzbauerORCiDGND, Jörg TrojanORCiDGND, Stefan ZeuzemORCiDGND, Peter Johannes WildORCiDGND, Dirk WalterGND |
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URN: | urn:nbn:de:hebis:30:3-798896 |
DOI: | https://doi.org/10.3390/jcm11072057 |
ISSN: | 2077-0383 |
Parent Title (English): | Journal of Clinical Medicine |
Publisher: | MDPI |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/04/06 |
Date of first Publication: | 2022/04/06 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2023/12/06 |
Tag: | chemotherapy; intrahepatic cholangiocarcinoma; liver fibrosis; overall survival |
Volume: | 11 |
Issue: | 7, art. 2057 |
Article Number: | 2057 |
Page Number: | 10 |
First Page: | 1 |
Last Page: | 10 |
HeBIS-PPN: | 516554778 |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |