The search result changed since you submitted your search request. Documents might be displayed in a different sort order.
  • search hit 1 of 2
Back to Result List

Phenotyping non‐alcoholic fatty liver disease by the gut microbiota: ready for prime time?

  • Background and Aim: Several studies observed alterations in the gut microbiota in patients with non‐alcoholic fatty liver disease (NAFLD). However, analyzed patient populations and methods strongly differ among these studies. The aim of this study was to prove the reproducibility of published results and to provide a detailed overview of all findings in our NAFLD cohort using next generation sequencing methods. Methods: The individual taxonomic microbiota composition of fecal samples from 90 NAFLD patients and 21 healthy controls was analyzed using 16S rRNA gene sequencing. Study participants were grouped according to their disease stage and compared regarding their gut microbiota composition. Studies were identified from PubMed listed publications, and the results were compared with the findings in our cohort. Results: Results from 13 identified studies were compared with our data. A decreased abundance of the Bacteroidetes and Ruminococcaceae as well as an increased abundance of Lactobacillaceae and Veillonellaceae and Dorea were the most frequently reported changes among NAFLD patients in 4/13, 5/13, 4/13, 2/13, and 3/13 studies, respectively. Even though these alterations in the gut microbiota composition were also observed in our patient cohort, the majority of published differences could not be reproduced, neither in our own nor in other NAFLD cohort studies. Conclusion: Despite repeatedly reproduced abundance patterns of specific bacteria, the heterogeneous study results did not reveal a consistent disease specific gut microbiota signature. Further prospective studies with homogenous patient cohorts and standardized methods are necessary to phenotype NAFLD by the gut microbiota.

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar
Metadaten
Author:Münevver Demir, Sonja Lang, Anna Martin, Fedja Farowski, Hilmar Wisplinghoff, Maria J. G. T. VehreschildORCiDGND, Marcin Krawczyk, Angela Nowag, Claus Jürgen Scholz, Anne Kretzschmar, Christoph Roderburg, Frank Lammert, Tobias Goeser, Philipp Kasper, Hans‐Michael Steffen
URN:urn:nbn:de:hebis:30:3-564028
DOI:https://doi.org/10.1111/jgh.15071
ISSN:1440-1746
ISSN:0815-9319
Parent Title (English):Journal of Gastroenterology and Hepatology
Publisher:Wiley-Blackwell
Place of publication:Oxford [u.a.]
Document Type:Article
Language:English
Date of Publication (online):2020/04/08
Date of first Publication:2020/04/08
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/12/07
Tag:NAFL; NASH; dysbiosis; microbiome
Volume:35
Issue:11
Page Number:9
First Page:1969
Last Page:1977
HeBIS-PPN:476624134
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0