Viola Knop, Daniel Hoppe, Johannes Vermehren, Sven Trötschler, Eva Herrmann, Annika Vermehren, Mireen Friedrich-Rust, Christoph Sarrazin, Jonel Trebicka, Stefan Zeuzem, Martin-Walter Welker
- Long-term effects on cirrhosis and portal hypertension of direct antiviral agent (DAA)-based eradication of hepatitis C virus (HCV) are still under debate. We analysed dynamics of liver and spleen elastography to assess potential regression of cirrhosis and portal hypertension 3 years post-treatment. Fifty-four patients with HCV-associated cirrhosis and DAA-induced SVR were included. Liver and spleen stiffness were measured at baseline (BL), end of treatment (EOT), 24 weeks after EOT (FU24) and 1, 2 and 3 (FU144) years post-treatment by transient liver elastography (L-TE) and point shear wave elastography (pSWE) using acoustic radiation force impulse (ARFI) of the liver (L-ARFI) and spleen (S-ARFI). Biochemical, virological and clinical data were also obtained. Liver stiffness assessed by L-TE decreased between BL [median (range), 32.5(9.1–75) kPa] and EOT [21.3(6.7–73.5) kPa; p < .0001] and EOT and FU144 [16(4.1–75) kPa; p = .006]. L-ARFI values improved between EOT [2.5(1.2–4.1) m/s] and FU144 [1.7(0.9–4.1) m/s; p = .001], while spleen stiffness remained unchanged. Overall, L-TE improved in 38 of 54 (70.4%) patients at EOT and 29 of 38 (76.3%) declined further until FU144, whereas L-ARFI values decreased in 30/54 (55.6%) patients at EOT and continued to decrease in 28/30 (93.3%) patients at FU144. Low bilirubin and high albumin levels at BL were associated with improved L-ARFI values (p = .048) at EOT or regression of cirrhosis (<12.5 kPa) by L-TE at FU144 (p = .005), respectively. Liver stiffness, but not spleen stiffness, continued to decline in a considerable proportion of patients with advanced liver disease after HCV eradication.
MetadatenAuthor: | Viola Knop, Daniel Hoppe, Johannes VermehrenGND, Sven Trötschler, Eva HerrmannORCiDGND, Annika Vermehren, Mireen Friedrich-RustORCiDGND, Christoph SarrazinGND, Jonel TrebickaORCiDGND, Stefan ZeuzemORCiDGND, Martin-Walter WelkerGND |
---|
URN: | urn:nbn:de:hebis:30:3-644234 |
---|
DOI: | https://doi.org/10.1111/jvh.13587 |
---|
ISSN: | 1365-2893 |
---|
Parent Title (English): | Journal of viral hepatitis |
---|
Publisher: | Wiley-Blackwell |
---|
Place of publication: | Oxford [u.a.] |
---|
Document Type: | Article |
---|
Language: | English |
---|
Date of Publication (online): | 2021/08/03 |
---|
Date of first Publication: | 2021/08/03 |
---|
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
---|
Release Date: | 2022/03/14 |
---|
Tag: | acoustic radiation force impulse; chronic hepatitis C; direct-acting antiviral (DAA) treatment; liver cirrhosis; portal hypertension; transient elastography |
---|
Volume: | 28 |
---|
Issue: | 11 |
---|
Page Number: | 10 |
---|
First Page: | 1604 |
---|
Last Page: | 1613 |
---|
HeBIS-PPN: | 494728604 |
---|
Institutes: | Medizin |
---|
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
---|
Sammlungen: | Universitätspublikationen |
---|
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
---|