- Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of the hair follicles leading to painful lesions, associated with increased levels of pro-inflammatory cytokines. Numerous guidelines recommend antibiotics like clindamycin and rifampicin in combination, as first-line systemic therapy in moderate-to-severe forms of inflammation. HS has been proposed to be mainly an auto-inflammatory disease associated with but not initially provoked by bacteria. Therefore, it has to be assumed that the pro-inflammatory milieu previously observed in HS skin is not solely dampened by the bacteriostatic inhibition of DNA-dependent RNA polymerase. To further clarify the mechanism of anti-inflammatory effects of rifampicin, ex vivo explants of lesional HS from 8 HS patients were treated with rifampicin, and its effect on cytokine production, immune cells as well as the expression of Toll-like receptor 2 (TLR2) were investigated. Analysis of cell culture medium of rifampicin-treated HS explants revealed an anti-inflammatory effect of rifampicin that significantly inhibiting interleukin (IL)-1β, IL-6, IL-8, IL-10 and tumour necrosis factor (TNF)-α production. Immunohistochemistry of the rifampicin-treated explants suggested a tendency for it to reduce the expression of TLR2 while not affecting the number of immune cells.
MetadatenVerfasserangaben: | Isabel HaferlandORCiD, Chantal M. WallenweinGND, Tanja Ickelsheimer, Sandra DiehlORCiD, Matthias WackerORCiDGND, Susanne SchiffmannORCiDGND, Claudia BürgerORCiDGND, Roland KaufmannGND, Anke KönigGND, Andreas PinterORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-753627 |
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DOI: | https://doi.org/10.1111/exd.14531 |
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ISSN: | 1600-0625 |
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Titel des übergeordneten Werkes (Englisch): | Experimental dermatology |
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Verlag: | Wiley-Blackwell |
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Verlagsort: | Oxford |
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Dokumentart: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Veröffentlichung (online): | 20.01.2022 |
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Datum der Erstveröffentlichung: | 20.01.2022 |
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Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Datum der Freischaltung: | 07.09.2023 |
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Freies Schlagwort / Tag: | anti-bacterial agents; anti-inflammatory agent; hidradenitis suppurativa; rifampin; therapeutics |
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Jahrgang: | 31 |
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Ausgabe / Heft: | 7 |
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Seitenzahl: | 9 |
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Erste Seite: | 1005 |
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Letzte Seite: | 1013 |
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Bemerkung: | Open access funding enabled and organized by Projekt DEAL. |
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HeBIS-PPN: | 51297991X |
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Institute: | Medizin |
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DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Lizenz (Deutsch): | Creative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International |
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