Ralf Sammy Patyna, Timon Sebastian Eckes, Benjamin Florian Koch, Stephan Sudowe, Anke Oftring, Niko Kohmer, Holger Rabenau, Sandra Ciesek, Parthenopi Despina Avaniadi, Rahel Elisabeth Steiner, Ingeborg A. Hauser, Josef Pfeilschifter, Christoph Betz
- The long-term effect of protection by two doses of SARS-CoV-2 vaccination in patients receiving chronic intermittent hemodialysis (CIHD) is an urging question. We investigated the humoral and cellular immune response of 42 CIHD patients who had received two doses of SARS-CoV-2 vaccine, and again after a booster vaccine with mRNA-1273 six months later. We measured antibody levels and SARS-CoV-2-specific surrogate neutralizing antibodies (SNA). Functional T cell immune response to vaccination was assessed by quantifying interferon-γ (IFN-γ) and IL-2 secreting T cells specific for SARS-CoV-2 using an ELISpot assay. Our data reveal a moderate immune response after the second dose of vaccination, with significantly decreasing SARS-CoV-2-specific antibody levels and less than half of the study group showed neutralizing antibodies six months afterwards. Booster vaccines increased the humoral response dramatically and led to a response rate of 89.2% for antibody levels and a response rate of 94.6% for SNA. Measurement in a no response/low response (NR/LR) subgroup of our cohort, which differed from the whole group in age and rate of immunosuppressive drugs, indicated failure of a corresponding T cell response after the booster vaccine. We strongly argue in favor of a regular testing of surrogate neutralizing antibodies and consecutive booster vaccinations for CIHD patients to provide a stronger and persistent immunity.
MetadatenAuthor: | Ralf Sammy PatynaGND, Timon Sebastian EckesORCiDGND, Benjamin Florian KochORCiDGND, Stephan Sudowe, Anke Oftring, Niko KohmerORCiDGND, Holger RabenauORCiDGND, Sandra CiesekORCiDGND, Parthenopi Despina AvaniadiGND, Rahel Elisabeth SteinerGND, Ingeborg A. HauserGND, Josef PfeilschifterGND, Christoph Betz |
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URN: | urn:nbn:de:hebis:30:3-862418 |
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DOI: | https://doi.org/10.3390/vaccines10040585 |
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ISSN: | 2076-393X |
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Parent Title (English): | Vaccines |
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Publisher: | MDPI |
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Place of publication: | Basel |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/04/11 |
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Date of first Publication: | 2022/04/11 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2024/08/19 |
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Tag: | COVID-19; SARS-CoV-2; T cell response; booster; hemodialysis; mRNA-1273; seroconversion; vaccination |
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Volume: | 10 |
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Issue: | 4, art. 585 |
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Article Number: | 585 |
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Page Number: | 9 |
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First Page: | 1 |
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Last Page: | 9 |
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Note: | The APC was funded by the University Library of Goethe University Frankfurt, Germany. |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Open-Access-Publikationsfonds: | Medizin |
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Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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