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Relapse surveillance of acute myeloid leukemia patients in first remission after consolidation chemotherapy: diagnostic value of regular bone marrow aspirations
- The optimal follow-up care for relapse detection in acute myeloid leukemia (AML) patients in first remission after consolidation therapy with intensive chemotherapy is not established. In this retrospective study, we evaluate the diagnostic value of an intensive relapse surveillance strategy by regular bone marrow aspirations (BMA) in these patients. We identified 86 patients with newly diagnosed non-promyelocytic AML who had reached complete remission (CR) after intensive induction and consolidation chemotherapy between 2007 and 2019. Annual relapse rates were 40%, 17%, and 2% in years 1–3, respectively. Patients in CR were surveilled by BMA scheduled every 3 months for 2 years, followed by BMA every 6 months. This surveillance regimen detected 29 of 55 relapses (53%), 11 of which were molecular relapses (20%). The remaining 26 of 55 relapses (47%) were diagnosed by non-surveillance BMA prompted by specific suspicion of relapse. Most patients showed concurrent morphological abnormalities in peripheral blood (PB) at time of relapse. Seven percent of all morphological relapses occurred without simultaneous PB abnormalities and would have been delayed without surveillance BMA. Intensified monthly PB assessment paired with BMA every 3 months during the first 2 years may be a highly sensitive relapse surveillance strategy.
Author: | Sebastian E. Koschade-RixnerORCiDGND, Jan Alexander StratmannORCiDGND, Fabian FinkelmeierORCiDGND, Sebastian Alexander WagnerORCiDGND, Jörg ChromikGND, Björn SteffenGND, Hubert ServeORCiDGND, Christian Hubertus BrandtsORCiDGND, Olivier Karl Friedrich BalloORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-694853 |
DOI: | https://doi.org/10.1007/s00277-022-04862-3 |
ISSN: | 1432-0584 |
Parent Title (English): | Annals of hematology |
Publisher: | Springer |
Place of publication: | Berlin ; Heidelberg ; New York |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/05/20 |
Date of first Publication: | 2022/05/20 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2023/05/11 |
Tag: | AML; Bone marrow aspiration; CBC; Peripheral blood smears; Relapse surveillance |
Volume: | 101 |
Issue: | 8 |
Page Number: | 8 |
First Page: | 1703 |
Last Page: | 1710 |
Note: | Open Access funding enabled and organized by Projekt DEAL. |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | ![]() |