Gilberto Sousa Alves, Laurence O’Dwyer, Alina Jurcoane, Viola Oertel-Knöchel, Christian Knöchel, David Prvulovic, Felipe Sudo, Carlos Eduardo Alves, Letice Valente, Denise Moreira, Fabian Fußer, Tarik Karakaya, Johannes Pantel, Eliasz Engelhardt, Jerson Laks
- Alzheimeŕs disease (AD) represents the most prevalent neurodegenerative disorder that causes cognitive decline in old age. In its early stages, AD is associated with microstructural abnormalities in white matter (WM). In the current study, multiple indices of diffusion tensor imaging (DTI) and brain volumetric measurements were employed to comprehensively investigate the landscape of AD pathology. The sample comprised 58 individuals including cognitively normal subjects (controls), amnestic mild cognitive impairment (MCI) and AD patients. Relative to controls, both MCI and AD subjects showed widespread changes of anisotropic fraction (FA) in the corpus callosum, cingulate and uncinate fasciculus. Mean diffusivity and radial changes were also observed in AD patients in comparison with controls. After controlling for the gray matter atrophy the number of regions of significantly lower FA in AD patients relative to controls was decreased; nonetheless, unique areas of microstructural damage remained, e.g., the corpus callosum and uncinate fasciculus. Despite sample size limitations, the current results suggest that a combination of secondary and primary degeneration occurrs in MCI and AD, although the secondary degeneration appears to have a more critical role during the stages of disease involving dementia.
MetadatenAuthor: | Gilberto Sousa Alves, Laurence O’Dwyer, Alina Jurcoane, Viola Oertel-KnöchelGND, Christian Knöchel, David Prvulovic, Felipe Sudo, Carlos Eduardo Alves, Letice Valente, Denise Moreira, Fabian FußerORCiDGND, Tarik Karakaya, Johannes PantelORCiDGND, Eliasz Engelhardt, Jerson Laks |
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URN: | urn:nbn:de:hebis:30:3-283639 |
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DOI: | https://doi.org/10.1371/journal.pone.0052859 |
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ISSN: | 1932-6203 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/23300797 |
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Parent Title (English): | PLoS One |
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Publisher: | PLoS |
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Place of publication: | Lawrence, Kan. |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2013/01/21 |
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Date of first Publication: | 2012/12/31 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2013/01/21 |
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Volume: | 7 |
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Issue: | (12): e52859 |
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Page Number: | 12 |
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Note: | Copyright: © 2012 Alves et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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HeBIS-PPN: | 321864662 |
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Institutes: | Psychologie und Sportwissenschaften / Psychologie |
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| Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 3.0 |
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