The macrophage iron signature in health and disease
- Throughout life, macrophages are located in every tissue of the body, where their main roles are to phagocytose cellular debris and recycle aging red blood cells. In the tissue niche, they promote homeostasis through trophic, regulatory, and repair functions by responding to internal and external stimuli. This in turn polarizes macrophages into a broad spectrum of functional activation states, also reflected in their iron-regulated gene profile. The fast adaptation to the environment in which they are located helps to maintain tissue homeostasis under physiological conditions.
Author: | Christina MertensORCiDGND, Oriana MarquesORCiDGND, Natalie HorvatORCiD, Manuela Simonetti, Martina Muckenthaler, Michaela JungORCiD |
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URN: | urn:nbn:de:hebis:30:3-626342 |
DOI: | https://doi.org/10.3390/ijms22168457 |
ISSN: | 1422-0067 |
Parent Title (English): | International journal of molecular sciences |
Publisher: | Molecular Diversity Preservation International |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/08/06 |
Date of first Publication: | 2021/08/06 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2021/09/28 |
Tag: | disordered iron metabolism; iron metabolism; macrophage polarization |
Volume: | 22 |
Issue: | 16, art. 8457 |
Page Number: | 30 |
First Page: | 1 |
Last Page: | 30 |
Note: | This research was funded by Wilhelm Sander-Stiftung (2017.130.2, awarded to M.J.). O.M.was supported by a Junior Research Grant from the European Hematology Association O.M. (EHA:RG-70). |
HeBIS-PPN: | 48757740X |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Open-Access-Publikationsfonds: | Medizin |
Licence (German): | Creative Commons - Namensnennung 4.0 |