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Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind

  • Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood. Therefore, the VEGF system serves as a promising therapeutic target for brain pathologies, but its simultaneous action on vascular cells paves the way for harmful side effects. To circumvent these deleterious effects, many studies have aimed to clarify whether VEGFs directly affect neural cells or if the effects are mediated secondarily via other cell types, like vascular cells. A great number of reports have shown the expression and function of VEGF receptors (VEGFRs), mainly VEGFR-1 and -2, in neural cells, where VEGFR-2 has been described as the major mediator of VEGF-A signals. This review aims to summarize and compare the divergent roles of VEGFR-1 and -2 during CNS development and homeostasis.

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Metadaten
Author:Ina M. Wittko-Schneider, Fabian T. Schneider, Karl PlateGND
URN:urn:nbn:de:hebis:30:3-291443
DOI:https://doi.org/10.1007/s00018-013-1279-3
ISSN:1420-682X
ISSN:1420-9071
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/23475067
Parent Title (English):Cellular and molecular life sciences
Publisher:Birkhäuser
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2013/03/12
Date of first Publication:2013/03/12
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/03/13
Tag:Brain development; Brain repair; Migration; Neural stem cells; Neurogenesis; VEGF receptors
Volume:70
Issue:10
Page Number:21
First Page:1705
Last Page:1725
Note:
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
HeBIS-PPN:334239737
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0