Unleashing the power of NK cells in anticancer immunotherapy

Due to their physiological role in removing damaged cells, natural killer (NK) cells represent ideal candidates for cellular immunotherapy in the treatment of cancer. Thereby, the cytotoxicity of NK cells is regulated by signals on both, the NK cells as well as the targeted tumor cells, and the interplay and balance of these signals determine the killing capacity of NK cells. One promising avenue in cancer treatment is therefore the combination of NK cell therapy with agents that either help to increase the killing capacity of NK cells or sensitize tumor cells to an NK cell-mediated attack. In this mini-review, we present different strategies that can be explored to unleash the potential of NK cell immunotherapy. In particular, we summarize how modulation of apoptosis signaling within tumor cells can be exploited to sensitize tumor cells to NK cell-mediated cytotoxicity.

Metadaten
Author:	Meike Vogler ORCiD GND, Senthan Shanmugalingam, Vinzenz Särchen ORCiD GND, Lisa Marie Reindl ORCiD, Victoria Grèze, Leon Buchinger, Michael Kühn, Evelyn Ullrich ORCiD GND
URN:	urn:nbn:de:hebis:30:3-626191
DOI:	https://doi.org/10.1007/s00109-021-02120-z
ISSN:	1432-1440
Parent Title (English):	Journal of molecular medicine
Publisher:	Springer
Place of publication:	Berlin; Heidelberg; New York, NY
Document Type:	Article
Language:	English
Date of Publication (online):	2021/08/09
Date of first Publication:	2021/08/09
Publishing Institution:	Universitätsbibliothek Johann Christian Senckenberg
Release Date:	2021/10/14
Tag:	Apoptosis; Cancer; Immunotherapy; Natural killer cells
Volume:	2021
Issue:	online version before inclusion in an issue
Page Number:	13
Note:	Open Access funding enabled and organized by Projekt DEAL. This work has been supported by the Deutsche Forschungsge- meinschaft DFG (CRC 1292 / IRTG).
HeBIS-PPN:	489232299
Institutes:	Medizin
Dewey Decimal Classification:	6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:	Universitätspublikationen
Licence (German):	Creative Commons - Namensnennung 4.0

Open Access