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STAT6-dependent collagen synthesis in human fibroblasts is induced by bovine milk

  • Since the domestication of the urus, 10.000 years ago, mankind utilizes bovine milk for different purposes. Besides usage as a nutrient also the external application of milk on skin has a long tradition going back to at least the ancient Aegypt with Cleopatra VII as a great exponent. In order to test whether milk has impact on skin physiology, cultures of human skin fibroblasts were exposed to commercial bovine milk. Our data show significant induction of proliferation by milk (max. 2,3-fold, EC50: 2,5% milk) without toxic effects. Surprisingly, bovine milk was identified as strong inducer of collagen 1A1 synthesis at both, the protein (4-fold, EC50: 0,09% milk) and promoter level. Regarding the underlying molecular pathways, we show functional activation of STAT6 in a p44/42 and p38-dependent manner. More upstream, we identified IGF-1 and insulin as key factors responsible for milk-induced collagen synthesis. These findings show that bovine milk contains bioactive molecules that act on human skin cells. Therefore, it is tempting to test the herein introduced concept in treatment of atrophic skin conditions induced e.g. by UV light or corticosteroids.

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Author:Stefan KippenbergerORCiDGND, Nadja Nicole ZöllerORCiDGND, Johannes KleemannORCiDGND, Jutta Müller, Roland KaufmannGND, Matthias HofmannGND, August BerndORCiDGND, Markus MeissnerORCiDGND, Eva Maria ValeskyORCiDGND
URN:urn:nbn:de:hebis:30:3-379836
DOI:https://doi.org/10.1371/journal.pone.0131783
ISSN:1932-6203
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/26134630
Parent Title (English):PLoS One
Publisher:PLoS
Place of publication:Lawrence, Kan.
Document Type:Article
Language:English
Date of Publication (online):2015/07/02
Date of first Publication:2015/07/02
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2015/08/05
Volume:10
Issue:(7): e0131783
Page Number:15
First Page:1
Last Page:15
Note:
Copyright: © 2015 Kippenberger et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
HeBIS-PPN:369869702
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0