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Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma

  • Chest trauma has a significant relevance on outcome after severe trauma. Clinically, impaired lung function typically occurs within 72 hours after trauma. However, the underlying pathophysiological mechanisms are still not fully elucidated. Therefore, we aimed to establish an experimental long-term model to investigate physiological, morphologic and inflammatory changes, after severe trauma. Male pigs (sus scrofa) sustained severe trauma (including unilateral chest trauma, femur fracture, liver laceration and hemorrhagic shock). Additionally, non-injured animals served as sham controls. Chest trauma resulted in severe lung damage on both CT and histological analyses. Furthermore, severe inflammation with a systemic increase of IL-6 (p = 0.0305) and a local increase of IL-8 in BAL (p = 0.0009) was observed. The pO2/FiO2 ratio in trauma animals decreased over the observation period (p < 0.0001) but not in the sham group (p = 0.2967). Electrical Impedance Tomography (EIT) revealed differences between the traumatized and healthy lung (p < 0.0001). In conclusion, a clinically relevant, long-term model of blunt chest trauma with concomitant injuries has been developed. This reproducible model allows to examine local and systemic consequences of trauma and is valid for investigation of potential diagnostic or therapeutic options. In this context, EIT might represent a radiation-free method for bedside diagnostics.

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Author:Klemens Horst, Tim-Philipp Simon, Roman PfeiferORCiDGND, Michel Paul Johan Teuben, Khalid Almahmoud, Zhi Qiao, Susana Aguiar Santos, Carlos Emilio Castelar Wembers, Steffen Leonhardt, Nicole Heussen, Philipp StörmannORCiDGND, Birgit AunerGND, Borna ReljaORCiDGND, Ingo MarziORCiDGND, Alexander Tobias Haug, Martijn van Griensven, Miriam KalbitzORCiDGND, Markus Huber-LangGND, René H. Tolba, Lucy Kathleen Reiss, Stefan Uhlig, Gernot Marx, Hans-Christoph Pape, Frank HildebrandORCiDGND
Pubmed Id:
Parent Title (English):Scientific reports
Publisher:Macmillan Publishers Limited, part of Springer Nature
Place of publication:[London]
Document Type:Article
Year of Completion:2016
Date of first Publication:2016/12/21
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/08/21
Tag:Diagnostic markers; Experimental models of disease; Respiratory signs and symptoms; Translational research; Trauma
Issue:Art. 39659
Page Number:13
First Page:1
Last Page:13
Rights and permissions: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0