Severe infection with multidrug-resistant Salmonella choleraesuis in a young patient with primary sclerosing cholangitis
- Massive global spread of multidrug-resistant (MDR) Salmonella spp. expressing extended-spectrum beta-lactamase (ESBL) and additional resistance to fluoroquinolones has often been attributed to high international mobility as well as excessive use of oral antibiotics in livestock farming. However, MDR Salmonella spp. have not been mentioned as a widespread pathogen in clinical settings so far. We demonstrate the case of a 25-year-old male with primary sclerosing cholangitis who tested positive for MDR Salmonella enterica serotype Choleraesuis expressing ESBL and fluoroquinolone resistance. The pathogen was supposedly acquired during a trip to Thailand, causing severe fever, cholangitis and pancreatitis. To our knowledge, this is the first report of Salmonella enterica serotype Choleraesuis in Europe expressing such a multidrug resistance pattern. ESBL resistance of Salmonella enterica spp. should be considered in patients with obstructive biliary tract pathology and travel history in endemic countries.
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| Author: | Philip FerstlORCiDGND, Claudia ReinheimerGND, Katalin Jozsa, Stefan ZeuzemORCiDGND, Volkhard A. J. KempfORCiDGND, Oliver WaidmannORCiDGND, Georgios Grammatikos |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-441308 |
| DOI: | https://doi.org/10.3748/wjg.v23.i11.2086 |
| ISSN: | 2219-2840 |
| ISSN: | 1007-9327 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/28373776 |
| Parent Title (English): | World journal of gastroenterology |
| Publisher: | WJG Press |
| Place of publication: | Beijing |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2017/04/06 |
| Date of first Publication: | 2017/03/21 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2017/04/06 |
| Tag: | Biliary physiology; Infectious disease; Multidrug resistance; Primary sclerosing cholangitis; Salmonella choleraesuis |
| Volume: | 23 |
| Issue: | 11 |
| Page Number: | 5 |
| First Page: | 2086 |
| Last Page: | 2089 |
| Note: | Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| HeBIS-PPN: | 421389737 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (English): |  Creative Commons - Namensnennung-Nicht kommerziell 4.0 |
