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Antitumor effect of MAb EMD 55900 depends on EGF-R expression and histopathology

  • The proliferative stimulus of the epidermal growth factor (EGF) in human epithelial cells is mediated by its binding to the external domain of the EGF receptor (EGF-R). The purpose of this study was to investigate whether growth arrest of tumors treated with anti-EGFR MAb (EMD 55900) was dependent on EGF-R expression and distinct histopathologic criteria of those neoplasms. Nine different adenocarcinomas, squamous cell carcinomas and two neoplastic epithelial cell lines (A431 and Detroit 562), which were characterized by high EGF-R expression, were xenotransplanted onto NMRI-nu/nu mice and treated with an anti-EGF-R antibody (EMD 55900). Results revealed that EGF-R expression and distinct histopathologic growth patterns play an important role for the therapeutic effect of the EGF-R antibody treatment. Tumors with high epithelial cellularity and little connective tissue responded to EMD 55900 treatment to a greater degree of growth reduction than tumors with lower cellularity. These results will be helpful for evaluation of patients who would benefit from tumor therapy with anti-EGF-R antibody.

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Author:Christine SolbachORCiDGND, Anja Sterner-Kock, Marc Roller, Hans-Georg Schnürch, Manfred Stegmüller, Gudrun Caspar-Bell, Petra-Maria Schumm-DraegerGND, Manfred KaufmannGND, Rainald Knecht
URN:urn:nbn:de:hebis:30:3-456163
DOI:https://doi.org/10.1038/sj.neo.7900236
ISSN:1476-5586
ISSN:1522-8002
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/11988843
Parent Title (English):Neoplasia
Publisher:Stockton Press
Place of publication:Basingstoke
Document Type:Article
Language:English
Year of Completion:2002
Year of first Publication:2002
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/02/06
Tag:EGFR; EMD 55900; EMD 72000; antibody; histology
Volume:4
Issue:3
Page Number:6
First Page:237
Last Page:242
Note:
User License: Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)
HeBIS-PPN:426736397
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0