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Immunomodulatory properties and molecular effects in inflammatory diseases of low-dose X-irradiation

  • Inflammatory diseases are the result of complex and pathologically unbalanced multicellular interactions. For decades, low-dose X-irradiation therapy (LD-RT) has been clinically documented to exert an anti-inflammatory effect on benign diseases and chronic degenerative disorders. By contrast, experimental studies to confirm the effectiveness and to reveal underlying cellular and molecular mechanisms are still at their early stages. During the last decade, however, the modulation of a multitude of immunological processes by LD-RT has been explored in vitro and in vivo. These include leukocyte/endothelial cell adhesion, adhesion molecule and cytokine/chemokine expression, apoptosis induction, and mononuclear/polymorphonuclear cell metabolism and activity. Interestingly, these mechanisms display comparable dose dependences and dose-effect relationships with a maximum effect in the range between 0.3 and 0.7 Gy, already empirically identified to be most effective in the clinical routine. This review summarizes data and models exploring the mechanisms underlying the immunomodulatory properties of LD-RT that may serve as a prerequisite for further systematic analyses to optimize low-dose irradiation procedures in future clinical practice.

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Metadaten
Author:Franz RödelORCiDGND, Benjamin FreyORCiD, Katrin Manda, Guido Hildebrandt, Stephanie HehlgansORCiDGND, Ludwig Keilholz, Michael H. Seegenschmiedt, Udo Sebastian GaiplORCiDGND, Claus RödelORCiDGND
URN:urn:nbn:de:hebis:30:3-286241
DOI:https://doi.org/10.3389/fonc.2012.00120
ISSN:2234-943X
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/23057008
Parent Title (English):Frontiers in oncology
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Language:English
Date of Publication (online):2012/09/25
Date of first Publication:2012/09/25
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/02/14
Tag:discontinuous dose dependency; immune modulation; inflammation; low-dose radiation therapy
Volume:2
Issue:Article 120
Page Number:9
Note:
Copyright: © 2012 Rödel, Frey, Manda, Hildebrandt, Hehlgans, Keilholz, Seegenschmiedt, Gaipl and Rödel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
HeBIS-PPN:331434210
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0