Kerstin Kempf, Martin Röhling, Winfried Banzer, Klaus-Michael Braumann, Martin Halle, Nina Schaller, David McCarthy, Hans Georg Predel, Isabelle Schenkenberger, Susanne Tan, Hermann Toplak, Stephan Martin, Aloys Berg
- Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle intervention alone. In the international, multicentre, randomised-controlled ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related- Health-Risk), overweight or obese participants with metabolic syndrome criteria (n = 463) were randomised into two groups and received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement. Data were collected at baseline, after 1, 3, 6, and 12 months. All datasets providing leptin data (n = 427) were included in this predefined subanalysis. Serum leptin levels significantly correlated with sex, body mass index, weight, and fat mass at baseline (p < 0.0001). Stronger leptin reduction has been observed in the intervention compared to the control group with the lowest levels after 1 month of intervention (estimated treatment difference −3.4 µg/L [1.4; 5.4] for females; −2.2 µg/L [1.2; 3.3] for males; p < 0.001 each) and was predictive for stronger reduction of body weight and fat mass (p < 0.001 each) over 12 months. Strongest weight loss was observed after 6 months (−5.9 ± 5.1 kg in females of the intervention group vs. −2.9 ± 4.9 kg in the control group (p < 0.0001); −6.8 ± 5.3 kg vs. −4.1 ± 4.4 kg (p = 0.003) in males) and in those participants with combined leptin and insulin decrease. A meal replacement-based lifestyle intervention effectively reduces leptin which is predictive for long-term weight loss.
MetadatenAuthor: | Kerstin KempfORCiDGND, Martin RöhlingORCiDGND, Winfried BanzerGND, Klaus-Michael BraumannORCiDGND, Martin HalleORCiDGND, Nina SchallerORCiDGND, David McCarthyORCiD, Hans Georg PredelGND, Isabelle Schenkenberger, Susanne TanORCiDGND, Hermann ToplakORCiDGND, Stephan MartinGND, Aloys BergORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-720933 |
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DOI: | https://doi.org/10.3390/nu14122537 |
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ISSN: | 2072-6643 |
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Parent Title (English): | Nutrients |
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Publisher: | MDPI |
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Place of publication: | Basel |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/06/18 |
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Date of first Publication: | 2022/06/18 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Contributing Corporation: | ACOORH Study Group |
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Release Date: | 2023/02/28 |
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Tag: | RCT; leptin; low-glycaemic meal replacement; multicentre study; protein-rich; weight reduction |
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Volume: | 14 |
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Issue: | 12, art. 2537 |
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Article Number: | 2537 |
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Page Number: | 14 |
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First Page: | 1 |
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Last Page: | 14 |
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Note: | This research was funded by Almased-Wellness-GmbH. |
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Note: | The datasets generated during and/or analysed during the current study are not publicly available but are available from the corresponding author on reasonable request. |
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HeBIS-PPN: | 50718260X |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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