Daniel Dubinski, Sae-Yeon Won, Martin Voß, Fee Keil, Wolfgang Miesbach, Bedjan Behmanesh, Max Dosch, Peter Baumgarten, Joshua D. Bernstock, Volker Seifert, Thomas Michael Freiman, Florian Geßler
- Glioblastoma (GBM) is a cancer type with high thrombogenic potential and GBM patients are therefore at a particularly high risk for thrombotic events. To date, only limited data on anticoagulation management after pulmonary embolism (PE) in GBM is available and the sporadic use of DOACs remains off-label. A retrospective cohort analysis of patients with GBM and postoperative, thoracic CT scan confirmed PE was performed. Clinical course, follow-up at 6 and 12 months and the overall survival (OS) were evaluated using medical charts and neuroradiological data. Out of 584 GBM patients, 8% suffered from postoperative PE. Out of these, 30% received direct oral anticoagulants (DOACs) and 70% low-molecular-weight heparin (LMWH) for therapeutic anticoagulation. There was no significant difference in major intracranial hemorrhage (ICH), re-thrombosis, or re-embolism between the two cohorts. Although statistically non-significant, a tendency to reduced mRS at 6 and 12 months was observed in the LMWH cohort. Furthermore, patients receiving DOACs had a statistical benefit in OS. In our analysis, DOACs showed a satisfactory safety profile in terms of major ICH, re-thrombosis, and re-embolism compared to LMWH in GBM patients with postoperative PE. Prospective, randomized trials are urgent to evaluate DOACs for therapeutic anticoagulation in GBM patients with PE.
MetadatenAuthor: | Daniel DubinskiORCiDGND, Sae-Yeon WonORCiDGND, Martin VoßORCiDGND, Fee KeilORCiDGND, Wolfgang MiesbachORCiDGND, Bedjan BehmaneshORCiDGND, Max DoschORCiD, Peter BaumgartenORCiDGND, Joshua D. BernstockORCiD, Volker SeifertORCiD, Thomas Michael FreimanORCiDGND, Florian GeßlerORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-636336 |
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DOI: | https://doi.org/10.1007/s10143-021-01539-9 |
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ISSN: | 1437-2320 |
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Parent Title (English): | Neurosurgical review |
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Publisher: | Springer |
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Place of publication: | Berlin ; Heidelberg ; New York |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/04/26 |
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Date of first Publication: | 2021/04/26 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2022/07/12 |
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Tag: | Direct oral anticoagulation; Glioblastoma survival; Low-molecular-weight heparin; Pulmonary embolism; Therapeutic anticoagulation |
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Volume: | 45 |
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Issue: | 1 |
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Page Number: | 7 |
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First Page: | 451 |
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Last Page: | 457 |
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Note: | Open Access funding enabled and organized by Projekt DEAL. |
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HeBIS-PPN: | 502147814 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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