EGFR signaling in lung fibrosis
- In this review article, we will first provide a brief overview of the ErbB receptor–ligand system and its importance in developmental and physiological processes. We will then review the literature regarding the role of ErbB receptors and their ligands in the maladaptive remodeling of lung tissue, with special emphasis on idiopathic pulmonary fibrosis (IPF). Here we will focus on the pathways and cellular processes contributing to epithelial–mesenchymal miscommunication seen in this pathology. We will also provide an overview of the in vivo studies addressing the efficacy of different ErbB signaling inhibitors in experimental models of lung injury and highlight how such studies may contribute to our understanding of ErbB biology in the lung. Finally, we will discuss what we learned from clinical applications of the ErbB1 signaling inhibitors in cancer in order to advance clinical trials in IPF.
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| Author: | Fabian SchrammORCiD, Liliana SchäferORCiD, Małgorzata WygreckaORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-831343 |
| DOI: | https://doi.org/10.3390/cells11060986 |
| ISSN: | 2073-4409 |
| Parent Title (English): | Cells |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2022/03/14 |
| Date of first Publication: | 2022/03/14 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2024/06/25 |
| Tag: | ErbB-signaling; TGF-α; TGF-β; amphiregulin; epidermal growth factor; epidermal growth factor receptor; idiopathic pulmonary fibrosis; lung fibrosis; neuregulin 1; pulmonary fibrosis; tyrosine kinase inhibitor |
| Volume: | 11.2022 |
| Issue: | 6, art. 986 |
| Article Number: | 986 |
| Page Number: | 15 |
| First Page: | 1 |
| Last Page: | 15 |
| Note: | Funding: German Center for Lung Research ; 82 DZL 005A1 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
