Exploring the multifunctionality of SR proteins
- Members of the arginine–serine-rich protein family (SR proteins) are multifunctional RNA-binding proteins that have emerged as key determinants for mRNP formation, identity and fate. They bind to pre-mRNAs early during transcription in the nucleus and accompany bound transcripts until they are translated or degraded in the cytoplasm. SR proteins are mostly known for their essential roles in constitutive splicing and as regulators of alternative splicing. However, many additional activities of individual SR proteins, beyond splicing, have been reported in recent years. We will summarize the different functions of SR proteins and discuss how multifunctionality can be achieved. We will also highlight the difficulties of studying highly versatile SR proteins and propose approaches to disentangle their activities, which is transferrable to other multifunctional RBPs.
| Author: | Irena SliškovićORCiD, Hannah EichORCiD, Michaela Müller-McNicollORCiD |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-864161 |
| DOI: | https://doi.org/10.1042/BST20210325 |
| ISSN: | 0300-5127 |
| Parent Title (English): | Biochemical Society transactions |
| Publisher: | Portland Press |
| Place of publication: | London |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2021/12/23 |
| Date of first Publication: | 2021/12/23 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2024/08/06 |
| Tag: | SR proteins; challenges; gene expression; multifunctionality |
| Volume: | 50 |
| Issue: | 1 |
| Page Number: | 12 |
| First Page: | 187 |
| Last Page: | 198 |
| HeBIS-PPN: | 520852893 |
| Institutes: | Biowissenschaften / Biowissenschaften |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
