Manifestation of palmoplantar pustulosis during or after infliximab therapy for plaque-type psoriasis : report on five cases

  • Infliximab is a monoclonal antibody directed against TNF-alpha. It has been approved for use in rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriatic arthritis and plaque-type psoriasis. In case reports, positive effects on pustular variants of psoriasis have also been reported. However, paradoxically, manifestation of pustular psoriasis and plaque-type psoriasis has been reported in patients treated with TNF antagonists including infliximab for other indications. Here, we report on 5 patients with chronic plaque-type psoriasis who developed palmoplantar pustulosis during or after discontinuation of infliximab therapy. In two of the five cases, manifestation of palmoplantar pustulosis was not accompanied by worsening of plaque-type psoriasis. Possibly, site-specific factors or a differential contribution of immunological processes modulated by TNF inhibitors to palmoplantar pustulosis and plaque-type psoriasis may have played a role.

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Author:Rotraut Mössner, Diamant ThaçiORCiD, Johannes Mohr, Sylvie Pätzold, Hans Peter Bertsch, Ullrich Krüger, Kristian ReichORCiDGND
Parent Title (English):Archives of dermatological research
Place of publication:Berlin ; Heidelberg ; New York
Document Type:Article
Year of Completion:2008
Date of first Publication:2008/02/01
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2008/11/12
GND Keyword:TNF; Antagonist; Infliximab; Pustulosis; Psoriasis
Page Number:5
First Page:101
Last Page:105
Open Access: This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Source:Arch Dermatol Res. 2008 March; 300(3): 101–105 ; doi:10.1007/s00403-008-0831-8 ;
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0