Genetic variation in Fcγ receptor IIa and risk of coronary heart disease : negative results from two large independent populations

  • Background The role of the Fcgamma receptor IIa (FcgammaRIIa), a receptor for C-reactive protein (CRP), the classical acute phase protein, in atherosclerosis is not yet clear. We sought to investigate the association of FcgammaRIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples. Methods FcgammaRIIa-R/H131 polymorphisms were determined in a population of 527 patients with a history of myocardial infarction and 527 age and gender matched controls drawn from a population-based MONICA- Augsburg survey. In the LURIC population, 2227 patients with angiographically proven CHD, defined as having at least one stenosis [greater than or equal to]50%, were compared with 1032 individuals with stenosis <50%. Results In both populations genotype frequencies of the FcgammaRIIa gene did not show a significant departure from the Hardy-Weinberg equilibrium. FcgammaRIIa R(-131)->H genotype was not independently associated with lower risk of CHD after multivariable adjustments, neither in the MONICA population (odds ratio (OR) 1.08; 95% confidence interval (CI) 0.81 to 1.44), nor in LURIC (OR 0.96; 95% CI 0.81 to 1.14). Conclusion Our results do not confirm an independent relationship between FcgammaRIIa genotypes and risk of CHD in these populations.

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Author:Mahir KarakasGND, Michael Marcus Hoffmann, Caren Vollmert, Dietrich RothenbacherORCiDGND, Christa MeisingerORCiD, Bernhard Rudolf WinkelmannGND, Natalie Khuseyinova, Bernhard O. BöhmGND, Thomas IlligORCiDGND, Winfried MärzORCiDGND, Wolfgang KoenigORCiD
Pubmed Id:
Parent Title (English):BMC medical genetics
Publisher:BioMed Central ; Springer
Place of publication:London ; Berlin ; Heidelberg
Document Type:Article
Date of Publication (online):2009/06/24
Date of first Publication:2009/05/29
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2009/06/24
Page Number:9
First Page:1
Last Page:9
© 2009 Karakas et al., licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source:BMC Medical Genetics 2009, 10:46 ; doi:10.1186/1471-2350-10-46 ;
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 2.0