Chemokine receptor-5Delta32 mutation is no risk factor for ischemic-type biliary lesion in liver transplantation

  • It has been shown that certain chemokine receptor polymorphisms may correspond to certain complications after organ transplantation. Ischemic-type biliary lesion (ITBL) encounters for major morbidity and mortality in liver transplant recipients. So far, the exact cause for ITBL remains unclear. Certain risk factors for the development of ITBL like donor age and cold ischemic time are well described. In a previous study, a 32-nucleotide deletion of the chemokine receptor-5Delta32 (CCR-5Delta32) was strongly associated with the incidence of ITBL in adult liver transplantation. This study re-evaluates the association of CCR-5Delta32 gene polymorphism and the incidence of ITBL. 169 patients were included into this retrospective analysis. 134 patients were homozygous for wild-type CCR-5, 33 patients heterozygous, and 2 patients were homozygous for CCR-5Delta32 mutation. There were no major differences in donor or recipients demographics. No association was found between CCR-5Delta32 mutation and the development of ITBL.We conclude that CCR-5Delta32 is no risk factor for the development of ITBL in our patient cohort.

Download full text files

Export metadata

Author:Christoph Heidenhain, Gero Puhl, Christian MönchGND, Anja Lautem, Peter Neuhaus
Pubmed Id:
Parent Title (English):Journal of transplantation
Place of publication:New York, NY
Contributor(s):Carlos Esquivel
Document Type:Article
Date of Publication (online):2009/08/10
Date of first Publication:2009/02/23
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2009/08/10
Issue:Art. 436515
Page Number:6
First Page:1
Last Page:6
Copyright © 2009 Christoph Heidenhain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source:Journal of Transplantation, Volume 2009, Article ID 436515, 6 pages ; doi:10.1155/2009/436515
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 3.0