The heterogeneity of disruptive behavior disorders – implications for neurobiological research and treatment

  • Disruptive behaviour disorders are reflected by a great variety of symptoms ranging from impulsive-hot tempered quarrels to purposeful and goal directed acts of cruelty. A growing body of data indicates that there are neurobiological factors that increase the risk for developing disruptive behaviour disorders. In this review, we give a broad overview of recent studies investigating physiological, neural, genetic factors, and specific neurotransmitter systems. We also discuss the impact of psychosocial risk and consider the effects of gene-environment interactions. Due to the heterogeneity of disruptive behaviour disorders, it is concluded that specific subtypes of disruptive behaviour should be considered both in terms their biological basis and in regard to specific treatment needs.

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Author:Christina StadlerORCiDGND, Fritz PoustkaGND, Philipp Sterzer
Pubmed Id:
Parent Title (English):Frontiers in psychiatry
Publisher:Frontiers Research Foundation
Place of publication:Lausanne
Contributor(s):Christina S. Barr
Document Type:Article
Year of Completion:2010
Date of first Publication:2010/10/12
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2010/10/26
Tag:aggression; conduct disorder; disruptive behaviour disorder; intervention; neurobiology; research; review
Issue:Art. 21
Page Number:14
First Page:1
Last Page:14
Copyright © 2010 Stadler, Poustka and Sterzer. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoDeutsches Urheberrecht