Treatment recommendations for psoriatic arthritis

  • Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion. Methods: Formal literature reviews of treatment for the most significant discrete clinical manifestations of PsA (skin and nails, peripheral arthritis, axial disease, dactylitis and enthesitis) were performed and published by members of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). Treatment recommendations were drafted for each of the clinical manifestations by rheumatologists, dermatologists and PsA patients based on the literature reviews and consensus opinion. The level of agreement for the individual treatment recommendations among GRAPPA members was assessed with an online questionnaire. Results: Treatment recommendations were developed for peripheral arthritis, axial disease, psoriasis, nail disease, dactylitis and enthesitis in the setting of PsA. In rotal, 19 recommendations were drafted, and over 80% agreement was obtained on 16 of them. In addition, a grid that factors disease severity into each of the different disease manifestations was developed to help the clinician with treatment decisions for the individual patient from an evidenced-based perspective. Conclusions: Treatment recommendations for the cardinal physical manifestations of PsA were developed based on a literature review and consensus between rheumatologists and dermatologists. In addition, a grid was established to assist in therapeutic reasoning and decision making for individual patients. It is anticipated that periodic updates will take place using this framework as new data become available.

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Author:Christopher T. Ritchlin, Arthur KavanaughORCiDGND, Dafna D. Gladman, Philip J. Mease, Philip Helliwell, Wolf-Henning BoehnckeORCiDGND, Kurt de Vlam, David Fiorentino, Oliver FitzGerald, Alice B. GottliebGND, Neil J. McHugh, Peter NashORCiD, Abrar A. Qureshi, Enrique R. Soriano, William J. Taylor
Parent Title (English):Annals of the Rheumatic Diseases
Document Type:Article
Year of Completion:2008
Year of first Publication:2008
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Contributing Corporation:Group for Research and Assessment of Psoriasis and Psoriatic Arthritis , GRAPPA
Release Date:2010/01/27
First Page:1387
Last Page:1394
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source:Annals of the Rheumatic Diseases, 68:1387-1394 ; doi:10.1136/ard.2008.094946 ;
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoDeutsches Urheberrecht