Regulation of cell death in cancer - possible implications for immunotherapy
- Since most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape. Therefore, evasion of programmed cell death may provide one possible explanation as to why cancer immunotherapy has so far only shown modest clinical benefits for children with cancer. A better understanding of the molecular mechanisms that regulate sensitivity and resistance to programmed cell death is expected to open new perspectives for the development of novel experimental treatment strategies to enhance the efficacy of cancer immunotherapy in the future.
| Author: | Simone FuldaORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-274105 |
| DOI: | https://doi.org/10.3389/fonc.2013.00029 |
| ISSN: | 2234-943X |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/23441073 |
| Parent Title (English): | Frontiers in oncology |
| Publisher: | Frontiers Media |
| Place of publication: | Lausanne |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2013/02/21 |
| Date of first Publication: | 2013/02/21 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2013/02/28 |
| Tag: | cell death; childhood cancer; immunotherapy; signal transduction |
| Volume: | 3 |
| Issue: | Article 29 |
| Page Number: | 5 |
| Note: | Copyright © 2013 Fulda. This is an open-access article distributed under the terms of the Creative Commons Commercial License http://creativecommons.org/licenses/by/3.0/ , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
| HeBIS-PPN: | 332979180 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
