Shifting the balance of mitochondrial apoptosis: therapeutic perspectives
- Signaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical signal transduction cascades that control the regulation of cell death. This pathway is typically altered in human cancers, thereby providing a suitable target for therapeutic intervention. Members of the Bcl-2 family of proteins as well as cell survival signaling cascades such as the PI3K/Akt/mTOR pathway are involved in the regulation of mitochondria-mediated apoptosis. Therefore, further insights into the molecular mechanisms that form the basis for the control of mitochondria-mediated apoptosis will likely open new perspectives to bypass evasion of apoptosis and treatment resistance in human cancers.
| Author: | Simone FuldaORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-286237 |
| DOI: | https://doi.org/10.3389/fonc.2012.00121 |
| ISSN: | 2234-943X |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/23061040 |
| Parent Title (English): | Frontiers in oncology |
| Publisher: | Frontiers Media |
| Place of publication: | Lausanne |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2012/10/08 |
| Date of first Publication: | 2012/10/08 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2013/02/14 |
| Tag: | PI3K; apoptosis; cancer; mitochondria |
| Volume: | 2 |
| Issue: | Article 121 |
| Page Number: | 4 |
| Note: | Copyright © 2012 Fulda. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
| HeBIS-PPN: | 331433079 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
