IAPs on the move : role of inhibitors of apoptosis proteins in cell migration
- Inhibitors of Apoptosis Proteins (IAPs) are a class of highly conserved proteins predominantly known for the regulation of caspases and immune signaling. However, recent evidence suggests a crucial role for these molecules in the regulation of tumor cell shape and migration by controlling MAPK, NF-κB and Rho GTPases. IAPs directly control Rho GTPases, thus regulating cell shape and migration. For instance, XIAP and cIAP1 function as the direct E3 ubiquitin ligases of Rac1 and target it for proteasomal degradation. IAPs are differentially expressed in tumor cells and have been targeted by several cancer therapeutic drugs that are currently in clinical trials. Here, we summarize the current knowledge on the role of IAPs in the regulation of cell migration and discuss the possible implications of these observations in regulating tumor cell metastases.
| Author: | Tripat Kaur Oberoi-Khanuja, Arun Murali, Krishnaraj RajalingamORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-293093 |
| DOI: | https://doi.org/10.1038/cddis.2013.311 |
| ISSN: | 2041-4889 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24008728 |
| Parent Title (English): | Cell death & disease |
| Publisher: | Nature Publishing Group |
| Place of publication: | London [u.a.] |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2013/09/05 |
| Date of first Publication: | 2013/09/05 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2013/09/19 |
| Tag: | IAPs; XIAP; cIAP1 BIR; metastases; migration; tumour |
| Volume: | 4 |
| Issue: | 784 |
| Page Number: | 9 |
| Note: | Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
| HeBIS-PPN: | 35311457X |
| Institutes: | Biochemie, Chemie und Pharmazie / Biochemie und Chemie |
| Medizin / Medizin | |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| Sammlungen: | Universitätspublikationen |
| Sammlung Biologie / Sondersammelgebiets-Volltexte | |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
