Thrombolysis in a stroke patient on dabigatran anticoagulation: case report and synopsis of published cases
- We present the case of an aphasic 77-year-old stroke patient with left distal M1 occlusion who received rt-PA for thrombolysis while on oral anticoagulant treatment with dabigatran (150 mg b.i.d.). Coagulation parameters were normal (thrombin time 20 s, aPTT 20 s, INR 1.08) and the patient improved from an NIHSS of 15 to 5 within 24 h with sonographic evidence of M1 recanalization. She did not develop intracranial bleeding complications but showed unusually large diffuse skin ecchymoses. In our report, we give an overview of all reported cases of thrombolysis under dabigatran anticoagulation and discuss the questions of medication adherence under novel oral anticoagulants (NOA) and the safety of NOA in terms of secondary intracerebral hemorrhage after stroke.
| Author: | Waltraud PfeilschifterORCiDGND, Mario Giovanni Rosario Abruscato, Susanne Hövelmann, Horst Baas |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-298760 |
| DOI: | https://doi.org/10.1159/000350570 |
| ISSN: | 1662-680X |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/23626566 |
| Parent Title (English): | Case reports in neurology |
| Publisher: | Karger |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2013 |
| Date of first Publication: | 2013/03/25 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2013/05/10 |
| Tag: | Anticoagulation; Atrial fibrillation; Fibrinolytic; Hemorrhage; Stroke; Thrombolysis |
| Volume: | 5 |
| Issue: | 1 |
| Page Number: | 6 |
| First Page: | 56 |
| Last Page: | 61 |
| Note: | This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
| HeBIS-PPN: | 339412739 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
