Depressive mood mediates the influence of social support on health-related quality of life in elderly, multimorbid patients

  • Background: It is not well established how psychosocial factors like social support and depression affect health-related quality of life in multimorbid and elderly patients. We investigated whether depressive mood mediates the influence of social support on health-related quality of life. Methods: Cross-sectional data of 3,189 multimorbid patients from the baseline assessment of the German MultiCare cohort study were used. Mediation was tested using the approach described by Baron and Kenny based on multiple linear regression, and controlling for socioeconomic variables and burden of multimorbidity. Results: Mediation analyses confirmed that depressive mood mediates the influence of social support on health-related quality of life (Sobel's p < 0.001). Multiple linear regression showed that the influence of depressive mood (beta = -0.341, p < 0.01) on health-related quality of life is greater than the influence of multimorbidity (beta = -0.234, p < 0.01). Conclusion: Social support influences health-related quality of life, but this association is strongly mediated by depressive mood. Depression should be taken into consideration in research on multimorbidity, and clinicians should be aware of its importance when caring for multimorbid patients.

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar
Author:Felix Sebastin Wicke, Corina GüthlinORCiDGND, Karola MergenthalORCiDGND, Jochen GensichenORCiDGND, Christin Löffler, Horst BickelGND, Wolfgang Maier, Steffi Gerlinde Riedel-HellerORCiDGND, Siegfried Weyerer, Birgitt WieseORCiDGND, Hans-Helmut König, Gerhard SchönORCiDGND, Heike Hansen, Hendrik van den BusscheORCiDGND, Martin SchererGND, Anne Maren DahlhausGND
Pubmed Id:
Parent Title (English):BMC family practice
Publisher:BioMed Central
Place of publication:London
Document Type:Article
Date of Publication (online):2014/04/08
Date of first Publication:2014/04/08
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2014/05/07
Tag:Chronic medical conditions; Coping; Depression; Elderly patients; Family practice; Health-related quality of life; Multimorbidity; Primary care; Social support
Page Number:11
© 2014 Wicke et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 2.0