Sustained release of triamcinolone acetonide from an intratympanically applied hydrogel designed for the delivery of high glucocorticoid doses

  • The pharmacokinetic properties and tolerability of a triamcinolone acetonide poloxamer 407 hydrogel for intratympanic application were investigated in a guinea pig model. Evaluation of in vivo release kinetics showed very high initial perilymph drug levels, with clinically relevant levels present for a minimum of 10 days. Assessment of auditory brainstem response thresholds showed a minimal, delayed and transient threshold shift, which was apparent on day 3 and resolved by day 10. No relevant histological changes of the middle and inner ear structures were noted, and hair cell counts showed no significant differences between treated and untreated ears. Thus, the triamcinolone-acetonide-loaded poloxamer 407 hydrogel is an effective vehicle for sustained high-dose inner ear glucocorticoid delivery.

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Author:Clemens Honeder, Elisabeth Engleder, Hanna Schöpper, Franz Gabor, Gottfried Reznicek, Jens Wagenblast, Wolfgang Gstoettner, Christoph Arnoldner
Pubmed Id:
Parent Title (English):Audiology & neurotology : basic science and clinical research in the auditory and vestibular system and diseases of the ear
Place of publication:Basel
Document Type:Article
Year of Completion:2014
Date of first Publication:2014/04/02
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2014/07/15
Tag:Glucocorticoids; Inner ear therapy; Intratympanic drug delivery; Perilymph; Round window membrane; Triamcinolone acetonide
Page Number:10
First Page:193
Last Page:202
This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (, applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell 3.0