Species differences in bacterial NhaA Na+/H+ exchangers
- Bacteria have adapted their NhaA Na(+)/H(+) exchangers responsible for salt homeostasis to their different habitats. We present an electrophysiological and kinetic analysis of NhaA from Helicobacter pylori and compare it to the previously investigated exchangers from Escherichia coli and Salmonella typhimurium. Properties of all three transporters are described by a simple model using a single binding site for H(+) and Na(+). We show that H.pylori NhaA only has a small acidic shift of its pH-dependent activity profile compared to the other transporters and discuss why a more drastic change in its pH activity profile is not physiologically required.
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| Author: | Octavian CălinescuORCiDGND, Eva Danner, Marc Böhm, Carola Hunte, Klaus FendlerORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-345764 |
| DOI: | https://doi.org/10.1016/j.febslet.2014.05.066 |
| ISSN: | 1873-3468 |
| ISSN: | 0014-5793 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/25017436 |
| Parent Title (English): | FEBS letters |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam [u. a.] |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2014/10/23 |
| Date of first Publication: | 2014/08/25 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2014/10/23 |
| Tag: | Cation/proton antiport; Escherichia coli; Helicobacter pylori; NhaA; Salmonella typhimurium; Solid supported membrane |
| Volume: | 558 |
| Issue: | 17 |
| Page Number: | 7 |
| First Page: | 3111 |
| Last Page: | 3116 |
| Note: | (c) 2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
| HeBIS-PPN: | 366546430 |
| Institutes: | Biochemie, Chemie und Pharmazie / Biochemie und Chemie |
| Angeschlossene und kooperierende Institutionen / MPI für Biophysik | |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| Sammlungen: | Sammlung Biologie / Sondersammelgebiets-Volltexte |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
