Recording of brain activity across spatial scales
- Brain activity reveals exquisite coordination across spatial scales, from local microcircuits to brain-wide networks. Understanding how the brain represents, transforms and communicates information requires simultaneous recordings from distributed nodes of whole brain networks with single-cell resolution. Realizing multi-site recordings from communicating populations is hampered by the need to isolate clusters of interacting cells, often on a day-to-day basis. Chronic implantation of multi-electrode arrays allows long-term tracking of activity. Lithography on thin films provides a means to produce arrays of variable resolution, a high degree of flexibility, and minimal tissue displacement. Sequential application of surface arrays to monitor activity across brain-wide networks and subsequent implantation of laminar arrays to target specific populations enables continual refinement of spatial scale while maintaining coverage.
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| Author: | Christopher Murphy LewisORCiD, Conrado A. BosmanORCiD, Pascal FriesORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-306328 |
| DOI: | https://doi.org/10.1016/j.conb.2014.12.007 |
| ISSN: | 0959-4388 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/25544724 |
| Parent Title (English): | Current Opinion in Neurobiology |
| Publisher: | Current Biology |
| Place of publication: | Philadelphia, Pa |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2014/12/24 |
| Date of first Publication: | 2014/12/24 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2016/06/14 |
| Volume: | 32 |
| Page Number: | 10 |
| First Page: | 68 |
| Last Page: | 77 |
| Note: | © 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/). |
| HeBIS-PPN: | 415316863 |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Keine kommerzielle Nutzung-Weitergabe unter gleichen Bedingungen |
