Treatment and pattern of bone metastases in 1094 patients with advanced breast cancer – results from the prospective German Tumour Registry Breast Cancer cohort study

  • A high proportion of patients with breast cancer develop bone metastases, yet data on routine treatment with bone-targeted agents (BTA) are rare. We report real-life outcome data of patients with breast cancer metastasised to the bone treated by office-based oncologists in Germany. The ongoing, prospective, multicentre, population-based cohort study Tumour Registry Breast Cancer (TMK) was started in 2007 in 140 centres across Germany. This interim analysis of 1094 patients with bone metastases revealed differences among the tumour subtypes: at start of first-line therapy, 36% of the patients with hormone receptor (HR)-positive and only 20% of the patients with HR-negative tumours presented with bone-only metastasis. The majority of patients with bone metastases (89%, n = 976) received BTA therapy. In 2014–2015, 37% of the patients received the bisphosphonate zoledronic acid and 36% the antibody denosumab. Median duration of BTA therapy was 20 months (interquartile range 31.5 months), starting a median of 3 weeks after diagnosis of bone metastases, and ending a median of 7 weeks before death. The median overall survival (OS) also varied among the types of metastasis at start of first-line therapy ranging from 54 months (95% confidence interval [CI] 37.6–70.8), 38 months (95% CI 29.4–44.2) to 28 months (95% CI 24.2–31.0) for patients with bone-only metastases, non-visceral with or without bone metastases and visceral with or without bone metastases respectively. We show that choice and duration of BTA therapies are in conformity with guidelines applicable in Germany. To our knowledge, this is the first presentation of data on incidence, metastatic pattern, treatment and survival of patients with bone metastases in routine practice.
Metadaten
Author:Jan Schröder, Thomas Fietz, Andreas Köhler, Volker Petersen, Hans TeschORCiDGND, Lisa Spring, Annette Fleitz, Martina JänickeGND, Norbert Marschner
URN:urn:nbn:de:hebis:30:3-439601
DOI:https://doi.org/10.1016/j.ejca.2017.03.031
ISSN:1879-0852
ISSN:1879-2995
ISSN:0959-8049
ISSN:0014-2964
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/28494404
Parent Title (English):European journal of cancer
Publisher:Elsevier
Place of publication:Amsterdam [u. a.]
Document Type:Article
Language:English
Date of Publication (online):2017/08/24
Date of first Publication:2017/05/08
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Contributing Corporation:TMK-Group (Tumour Registry Breast Cancer)
Release Date:2017/08/24
Tag:Bone metastasis; Breast neoplasms; Cohort studies; Denosumab; Diphosphonates; Outcome assessment; Outpatients; Registries
Volume:79
Page Number:10
First Page:139
Last Page:148
Note:
© 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
HeBIS-PPN:423895400
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0