Impact of human mesenchymal stromal cells on antifungal host response against Aspergillus fumigatus

  • Mesenchymal stromal cells (MSCs) are increasingly given as immunotherapy to hematopoietic stem cell transplant (HSCT) recipients with refractory graft-versus-host disease (GvHD). Whereas the immunosuppressive properties of MSCs seem to be beneficial in GvHD, there is, at the same time, major concern that MSCs increase the risk for infection. We therefore investigated the interplay of human MSCs with Aspergillus fumigatus and the impact of MSCs on different arms of the anti-Aspergillus host response in vitro. Although A. fumigatus hyphae increase mRNA levels of IL6 in MSCs, the extracellular availability of IL-6 and other pro-inflammatory cytokines remains unaffected. Human MSCs are able to phagocyte Aspergillus conidia, but phagocytosis of conidia is not associated with an alteration of the cytokine production by MSCs. In addition, human MSCs do not affect activation and function of A. fumigatus specific CD4+ T cells, and MSCs do not negatively impact the oxidative burst activity of phagocytes. Our in vitro data indicate that administration of human MSCs is not associated with a negative impact on the host response against A. fumigatus and that the fungus does not stimulate MSCs to increase the release of those cytokines which play a central role in the pathophysiology of GvHD.

Download full text files

Export metadata

Metadaten
Author:Stanislaw Schmidt, Lars Tramsen, Andreas Schneider, Ralf SchubertORCiDGND, Ada Balan, Özer Degistirici, Roland MeiselORCiDGND, Thomas LehrnbecherORCiDGND
URN:urn:nbn:de:hebis:30:3-451826
DOI:https://doi.org/10.18632/oncotarget.20753
ISSN:1949-2553
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/29221143
Parent Title (English):OncoTarget
Publisher:Impact Journals LLC
Place of publication:[s. l.]
Document Type:Article
Language:English
Year of Completion:2017
Date of first Publication:2017/09/08
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2017/12/14
Tag:Aspergillus fumigatus; hematopoietic stem cell transplantation; immunotherapy; mesenchymal stromal cells; phagocytosis
Volume:8
Issue:56
Page Number:9
First Page:95495
Last Page:95503
Note:
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
HeBIS-PPN:426120264
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0