Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy

  • Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult to make. Here, we report a genome-wide association study on food allergy diagnosed by oral food challenge in 497 cases and 2387 controls. We identify five loci at genome-wide significance, the clade B serpin (SERPINB) gene cluster at 18q21.3, the cytokine gene cluster at 5q31.1, the filaggrin gene, the C11orf30/LRRC32 locus, and the human leukocyte antigen (HLA) region. Stratifying the results for the causative food demonstrates that association of the HLA locus is peanut allergy-specific whereas the other four loci increase the risk for any food allergy. Variants in the SERPINB gene cluster are associated with SERPINB10 expression in leukocytes. Moreover, SERPINB genes are highly expressed in the esophagus. All identified loci are involved in immunological regulation or epithelial barrier function, emphasizing the role of both mechanisms in food allergy.
Metadaten
Author:Ingo Marenholz, Sarah Grosche, Birgit Kalb, Franz RüschendorfORCiD, Katharina BlümchenORCiDGND, Rupert Schlags, Neda Harandi, Mareike Price, Gesine HansenORCiDGND, Jürgen SeidenbergGND, Holger Röblitz, Songül Yürek, Sebastian Tschirner, Xiumei Hong, Xiaobin Wang, Georg HomuthORCiD, Carsten Schmidt, Markus Maria NöthenORCiDGND, Norbert Hübner, Bodo Niggemann, Kirsten BeyerORCiDGND, Young-Ae Lee
URN:urn:nbn:de:hebis:30:3-469661
DOI:https://doi.org/10.1038/s41467-017-01220-0
ISSN:2041-1723
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/29051540
Parent Title (English):Nature Communications
Publisher:Nature Publishing Group UK
Place of publication:[London]
Document Type:Article
Language:English
Year of Completion:2017
Date of first Publication:2017/10/20
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/09/18
Tag:Allergy; Genome-wide association studies
Volume:8
Issue:1, Art. 1056
Page Number:10
First Page:1
Last Page:10
Note:
Rights and permissions: Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
HeBIS-PPN:437748421
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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