Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic aging

  • In aerobic organisms, mitochondrial F1Fo-ATP-synthase is the major site of ATP production. Beside this fundamental role, the protein complex is involved in shaping and maintenance of cristae. Previous electron microscopic studies identified the dissociation of F1Fo-ATP-synthase dimers and oligomers during organismic aging correlating with a massive remodeling of the mitochondrial inner membrane. Here we report results aimed to experimentally proof this impact and to obtain further insights into the control of these processes. We focused on the role of the two dimer assembly factors PaATPE and PaATPG of the aging model Podospora anserina. Ablation of either protein strongly affects mitochondrial function and leads to an accumulation of senescence markers demonstrating that the inhibition of dimer formation negatively influences vital functions and accelerates organismic aging. Our data validate a model that links mitochondrial membrane remodeling to aging and identify specific molecular components triggering this process.

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Metadaten
Author:Nadia Giusi Rampello, Maria Stenger, Benedikt Westermann, Heinz D. OsiewaczORCiDGND
URN:urn:nbn:de:hebis:30:3-525542
DOI:https://doi.org/10.15698/mic2018.04.625
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/29610761
Parent Title (English):Microbial cell
Document Type:Article
Language:English
Date of Publication (online):2018/01/30
Date of first Publication:2018/01/30
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/01/23
Tag:F1Fo-ATP-synthase; aging; membranes; mitochondria; remodeling
Volume:5
Issue:4
Page Number:10
First Page:198
Last Page:207
Note:
© 2018 Rampello et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged
HeBIS-PPN:45984735X
Institutes:Biowissenschaften / Biowissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0