New oral anticoagulants in patients with nonvalvular atrial fibrillation: a review of pharmacokinetics, safety, efficacy, quality of life, and cost effectiveness

  • Atrial fibrillation (AF) continues to be a leading cause of cerebrovascular morbidity and mortality resulting from cardioembolic stroke. Oral anticoagulation therapy has been shown to decrease the incidence of cardioembolic stroke in patients with AF by more than 50%. Appropriate use of anticoagulation with vitamin K antagonists requires precise adherence and monitoring. A number of factors that potentially induce patients' dissatisfaction reduce quality of patient life. New direct oral anticoagulants, such as the direct factor Xa inhibitors rivaroxaban, apixaban, edoxaban, and the thrombin inhibitor dabigatran, were developed to overcome the limitations of the conventional anticoagulant drugs. However, models to optimize the benefit of therapy and to ensure that therapy can be safely continued are missing for the new oral anticoagulants. This review will briefly describe the new oral anticoagulants dabigatran, rivaroxaban, apixaban, and edoxaban with focus on their use for prevention of embolic events in AF. Moreover, it will discuss the safety, efficacy, cost data, and benefit for patients' quality of life and adherence.
Metadaten
Author:Helen ManiGND, Edelgard Lindhoff-LastORCiDGND
URN:urn:nbn:de:hebis:30:3-543098
DOI:https://doi.org/10.2147/DDDT.S45644
ISSN:1177-8881
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/24970997
Parent Title (English):Drug design, development and therapy
Publisher:Dove Medical Press
Place of publication:Albany, Auckland
Document Type:Article
Language:English
Date of Publication (online):2014/06/17
Date of first Publication:2014/06/17
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2020/05/24
Tag:apixaban; dabigatran; edoxaban; oral anticoagulation; rivaroxaban
Volume:8
Page Number:10
First Page:789
Last Page:798
HeBIS-PPN:46595913X
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell 3.0