MicroRNAs as emerging regulators of signaling in the tumor microenvironment
- A myriad of signaling molecules in a heuristic network of the tumor microenvironment (TME) pose a challenge and an opportunity for novel therapeutic target identification in human cancers. MicroRNAs (miRs), due to their ability to affect signaling pathways at various levels, take a prominent space in the quest of novel cancer therapeutics. The role of miRs in cancer initiation, progression, as well as in chemoresistance, is being increasingly investigated. The canonical function of miRs is to target mRNAs for post-transcriptional gene silencing, which has a great implication in first-order regulation of signaling pathways. However, several reports suggest that miRs also perform non-canonical functions, partly due to their characteristic non-coding small RNA nature. Examples emerge when they act as ligands for toll-like receptors or perform second-order functions, e.g., to regulate protein translation and interactions. This review is a compendium of recent advancements in understanding the role of miRs in cancer signaling and focuses on the role of miRs as novel regulators of the signaling pathway in the TME.
| Author: | Shahzad Nawaz SyedORCiDGND, Bernhard BrüneORCiD |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-543282 |
| DOI: | https://doi.org/Cancers 2020, 12(4), 911; https://doi.org/10.3390/cancers12040911 |
| ISSN: | 2072-6694 |
| Parent Title (English): | Cancers |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2020/04/08 |
| Date of first Publication: | 2020/04/08 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2020/05/05 |
| Tag: | RNA therapeutics; breast cancer; cancer; carcinoma; inflammation; microRNA |
| Volume: | 12 |
| Issue: | 911 |
| Page Number: | 18 |
| Note: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| HeBIS-PPN: | 465063969 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Open-Access-Publikationsfonds: | Medizin |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
