MicroRNAs as emerging regulators of signaling in the tumor microenvironment

  • A myriad of signaling molecules in a heuristic network of the tumor microenvironment (TME) pose a challenge and an opportunity for novel therapeutic target identification in human cancers. MicroRNAs (miRs), due to their ability to affect signaling pathways at various levels, take a prominent space in the quest of novel cancer therapeutics. The role of miRs in cancer initiation, progression, as well as in chemoresistance, is being increasingly investigated. The canonical function of miRs is to target mRNAs for post-transcriptional gene silencing, which has a great implication in first-order regulation of signaling pathways. However, several reports suggest that miRs also perform non-canonical functions, partly due to their characteristic non-coding small RNA nature. Examples emerge when they act as ligands for toll-like receptors or perform second-order functions, e.g., to regulate protein translation and interactions. This review is a compendium of recent advancements in understanding the role of miRs in cancer signaling and focuses on the role of miRs as novel regulators of the signaling pathway in the TME.

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar
Author:Shahzad Nawaz SyedORCiDGND, Bernhard BrüneORCiD
DOI:https://doi.org/Cancers 2020, 12(4), 911; https://doi.org/10.3390/cancers12040911
Parent Title (English):Cancers
Place of publication:Basel
Document Type:Article
Date of Publication (online):2020/04/08
Date of first Publication:2020/04/08
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/05/05
Tag:RNA therapeutics; breast cancer; cancer; carcinoma; inflammation; microRNA
Page Number:18
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0