Structural brain signature of cognitive decline in Parkinson’s disease: DTI-based evidence from the LANDSCAPE study

  • Background: The nonmotor symptom spectrum of Parkinson’s disease (PD) includes progressive cognitive decline mainly in late stages of the disease. The aim of this study was to map the patterns of altered structural connectivity of patients with PD with different cognitive profiles ranging from cognitively unimpaired to PD-associated dementia. Methods: Diffusion tensor imaging and neuropsychological data from the observational multicentre LANDSCAPE study were analyzed. A total of 134 patients with PD with normal cognitive function (56 PD-N), mild cognitive impairment (67 PD-MCI), and dementia (11 PD-D) as well as 72 healthy controls were subjected to whole-brain-based fractional anisotropy mapping and covariance analysis with cognitive performance measures. Results: Structural data indicated subtle changes in the corpus callosum and thalamic radiation in PD-N, whereas severe white matter impairment was observed in both PD-MCI and PD-D patients including anterior and inferior fronto-occipital, uncinate, insular cortices, superior longitudinal fasciculi, corona radiata, and the body of the corpus callosum. These regional alterations were demonstrated for PD-MCI and were more pronounced in PD-D. The pattern of involved regions was significantly correlated with the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) total score. Conclusions: The findings in PD-N suggest impaired cross-hemispherical white matter connectivity that can apparently be compensated for. More pronounced involvement of the corpus callosum as demonstrated for PD-MCI together with affection of fronto-parieto-temporal structural connectivity seems to lead to gradual disruption of cognition-related cortico-cortical networks and to be associated with the onset of overt cognitive deficits. The increase of regional white matter damage appears to be associated with the development of PD-associated dementia.
Metadaten
Author:Martin Gorges, Hans-Peter Müller, Inga Liepelt-Scarfone, Alexander Storch, Richard Dodel, Rüdiger Hilker-RoggendorfGND, Daniela Berg, Martin S. Kunz, Elke Kalbe, Simon Baudrexel, Jan Kassubek
URN:urn:nbn:de:hebis:30:3-543898
DOI:https://doi.org/10.1177/1756286419843447
ISSN:1756-2864
ISSN:1756-2856
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/31205489
Parent Title (English):Therapeutic advances in neurological disorders
Publisher:SAGE Publications
Place of publication:London [u. a.]
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/05/16
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Contributing Corporation:LANDSCAPE Consortium
Release Date:2020/05/27
Tag:dementia; diffusion tensor imaging; magnetic resonance imaging; mild cognitive impairment
Volume:12
Page Number:15
First Page:1
Last Page:15
Note:
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
HeBIS-PPN:466162049
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0