The fire and ice trial: What we know, what we can still learn, and what we need to address in the future

  • The FIRE AND ICE Trial (ClinicalTrials.gov, identifier NCT01490814) was initiated in 2012 as a multicenter, randomized, head‐to‐head comparison of radiofrequency current (RFC) and cryoballoon catheter ablation for the treatment of patients with drug‐refractory symptomatic paroxysmal atrial fibrillation (AF). Six years on, it remains the largest, randomized comparison of safety and efficacy between 2 catheter ablation modalities used in the treatment of patients with AF. This landmark trial not only established noninferiority between cryoballoon and RFC ablation for pulmonary vein isolation (PVI) with regard to the study's efficacy and safety primary end points,1 but also, it evaluated secondary end points that were critical for a representative study interpretation. ...

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Author:Karl-Heinz Kuck, Josep Brugada, Michael Schlüter, Kendra M. Braegelmann, Fred J. Kueffer, Kyoung-Ryul Julian Chun, Jean-Paul Albenque, Claudio Tondo, Hugh Calkins
URN:urn:nbn:de:hebis:30:3-544663
DOI:https://doi.org/10.1161/JAHA.118.010777
ISSN:2047-9980
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30561258
Parent Title (English):Journal of the American Heart Association
Publisher:Association
Place of publication:New York, NY
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/12/10
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Contributing Corporation:FIRE AND ICE Trial Investigators
Release Date:2020/05/04
Tag:atrial fibrillation; catheter ablation; radiofrequency
Volume:18
Issue:24
Page Number:10
First Page:1
Last Page:10
Note:
Copyright © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
HeBIS-PPN:465981747
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0