Macrophage activation markers, CD163 and CD206, in acute-on-chronic liver failure

  • Macrophages facilitate essential homeostatic functions e.g., endocytosis, phagocytosis, and signaling during inflammation, and express a variety of scavenger receptors including CD163 and CD206, which are upregulated in response to inflammation. In healthy individuals, soluble forms of CD163 and CD206 are constitutively shed from macrophages, however, during inflammation pathogen- and damage-associated stimuli induce this shedding. Activation of resident liver macrophages viz. Kupffer cells is part of the inflammatory cascade occurring in acute and chronic liver diseases. We here review the existing literature on sCD163 and sCD206 function and shedding, and potential as biomarkers in acute and chronic liver diseases with a particular focus on Acute-on-Chronic Liver Failure (ACLF). In multiple studies sCD163 and sCD206 are elevated in relation to liver disease severity and established as reliable predictors of morbidity and mortality. However, differences in expression- and shedding-stimuli for CD163 and CD206 may explain dissimilarities in prognostic utility in patients with acute decompensation of cirrhosis and ACLF.

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Author:Marlene Christina Nielsen, Rasmus Hvidbjerg Gantzel, Joan Clària, Jonel TrebickaORCiDGND, Holger Jon Møller, Henning Grønbæk
Parent Title (English):Cells
Place of publication:Basel
Document Type:Article
Date of Publication (online):2020/05/09
Date of first Publication:2020/05/09
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/06/11
Tag:ACLF; acute decompensation of cirrhosis; acute-on-chronic liver failure; chronic liver disease; inflammation; liver cirrhosis; macrophage; sCD163; sCD206; scavenger receptor
Page Number:18
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0