Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial

  • Background: Many patients suffering from exercise-induced asthma (EIA) have normal lung function at rest and show symptoms and a decline in FEV1 when they do sports or during exercise-challenge. It has been described that long-chain polyunsaturated fatty acids (LCPUFA) could exert a protective effect on EIA. Methods: In this study the protective effect of supplementation with a special combination of n-3 and n-6 LCPUFA (sc-LCPUFA) (total 1.19 g/ day) were investigated in an EIA cold air provocation model. Primary outcome measure: Decrease in FEV1 after exercise challenge and secondary outcome measure: anti-inflammatory effects monitored by exhaled NO (eNO) before and after sc-LCPUFA supplementation versus placebo. Results: Ninety-nine patients with exercise-induced symptoms aged 10 to 45 were screened by a standardized exercise challenge in a cold air chamber at 4 °C. Seventy-three patients fulfilled the inclusion criteria of a FEV1 decrease > 15% and were treated double-blind placebo-controlled for 4 weeks either with sc-LCPUFA or placebo. Thirty-two patients in each group completed the study. Mean FEV1 decrease after cold air exercise challenge and eNO were unchanged after 4 weeks sc-LCPUFA supplementation. Conclusion: Supplementation with sc-LCPUFA at a dose of 1.19 g/d did not have any broncho-protective and anti-inflammatory effects on EIA. Trial registration: Clinical trial registration number: NCT02410096. Registered 7 February 2015 at Clinicaltrial.gov
Author:Melanie DreßlerORCiDGND, Daniela FußbroichORCiDGND, Lisa Böhler, Eva HerrmannORCiDGND, Nicole Benker, Markus Tytyk, Johannes B. SchulzeORCiDGND, Ralf SchubertORCiDGND, Christopher Beermann, Stefan ZielenORCiDGND
Parent Title (English):Lipids in health and disease
Publisher:Biomed Central
Place of publication:London
Document Type:Article
Date of Publication (online):2020/07/13
Date of first Publication:2020/07/13
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/09/03
Tag:Double-blind placebo-controlled trial; Exercise challenge; Exercise-induced asthma; Exhaled nitric oxide; Forced expiratory volume in 1 s; Longchain polyunsaturated fatty acids
Issue:art. 167
Page Number:10
First Page:1
Last Page:10
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Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
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