Gene expression signature of acquired chemoresistance in neuroblastoma cells

  • Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify chemoresistance gene expression signatures in vincristine resistant neuroblastoma cells. We found that vincristine-resistant neuroblastoma cells formed larger clones and survived under reduced serum conditions as compared with non-resistant parental cells. To identify the possible mechanisms underlying vincristine resistance in neuroblastoma cells, we investigated the expression profiles of genes known to be involved in cancer drug resistance. This specific gene expression patterns could predict the behavior of a tumor in response to chemotherapy and for predicting the prognosis of high-risk neuroblastoma patients. Our signature could help chemoresistant neuroblastoma patients in avoiding useless and harmful chemotherapy cycles.

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Author:Mohamed Jemaà, Wondossen Sime, Yasmin Abassi, Vito Alessandro Lasorsa, Julie Bonne Køhler, Martin MichaelisORCiDGND, Jindrich CinatlORCiDGND, Mario Capasso, Ramin Massoumi
Parent Title (English):International journal of molecular sciences
Place of publication:Basel
Document Type:Article
Date of Publication (online):2020/09/16
Date of first Publication:2020/09/16
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/09/17
Tag:chemoresistance; neuroblastoma; vincristine
Issue:(18), article 6811
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0