Consecutive treatment with brain-derived neurotrophic factor and electrical stimulation has a protective effect on primary auditory neurons

  • Degeneration of neurons, such as the inner ear spiral ganglion neurons (SGN), may be decelerated or even stopped by neurotrophic factor treatment, such as brain-derived neurotrophic factor (BDNF), as well as electrical stimulation (ES). In a clinical setting, drug treatment of the SGN could start directly during implantation of a cochlear implant, whereas electrical stimulation begins days to weeks later. The present study was conducted to determine the effects of consecutive BDNF and ES treatments on SGN density and electrical responsiveness. An electrode drug delivery device was implanted in guinea pigs 3 weeks after deafening and five experimental groups were established: two groups received intracochlear infusion of artificial perilymph (AP) or BDNF; two groups were treated with AP respectively BDNF in addition to ES (AP + ES, BDNF + ES); and one group received BDNF from the day of implantation until day 34 followed by ES (BDNF ⇨ ES). Electrically evoked auditory brainstem responses were recorded. After one month of treatment, the tissue was harvested and the SGN density was assessed. The results show that consecutive treatment with BDNF and ES was as successful as the simultaneous combined treatment in terms of enhanced SGN density compared to the untreated contralateral side but not in regard to the numbers of protected cells.

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Author:Verena Scheper, Ira Seidel-Effenberg, Thomas LenarzORCiDGND, Timo StöverGND, Gerrit Paasche
URN:urn:nbn:de:hebis:30:3-555810
DOI:https://doi.org/10.3390/brainsci10080559
ISSN:2076-3425
Parent Title (English):Brain Sciences
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2020/08/15
Date of first Publication:2020/08/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/09/14
Tag:BDNF; ES; cochlear implant; drug delivery; inner ear therapy; spiral ganglion cells
Volume:10
Issue:(8), art. 559
Page Number:13
HeBIS-PPN:47076418X
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0