Treatment response lowers tumor symptom burden in recurrent and/or metastatic head and neck cancer

  • Background: Head and neck squamous cell cancer (HNSCC) frequently causes severe symptoms that may be reduced, when the tumor is successfully treated. The SOCCER trial studied the association of treatment response with patient reported tumor symptom burden in first line treatment of recurrent and/or metastatic HNSCC. Methods: In this prospective, multi-center, non-interventional trial patients were treated either with platinum-based chemotherapy and cetuximab or radiotherapy and cetuximab. Tumor symptom burden was assessed every four weeks with a questionnaire containing ten visual analogue scales (VAS, range 0–100), which were summarized to the overall VAS score. Results: Fourhundred seventy patients were registered in 97 German centers. A total of 315 patients with at least the baseline and one subsequent questionnaire were available for analysis. Changes in the VAS score were rated as absolute differences from baseline. Negative values indicate improvement of symptoms. The overall VAS score improved significantly at the first post-baseline assessment in responders (− 2.13 vs. non-responders + 1.15, p = 0.048), and even more for the best post-baseline assessment (− 7.82 vs. non-responders − 1.97, p = 0.0005). The VAS for pain (− 16.37 vs. non-responders − 8.89, p = 0.001) and swallowing of solid food (− 16.67 vs. non-responders − 5.06, p = 0.002) improved significantly more in responders (best post-baseline assessment). In the multivariable Cox regression analysis, worse overall VAS scores were associated with worse overall survival (hazard ratio for death 1.12 per 10 points increment on the overall VAS scale, 95% CI 1.05–1.20, p = 0.0009). Conclusion: In unselected patients beyond randomized controlled trials, treatment response lowers tumor symptom burden in recurrent and/or metastatic HNSCC. Trial registration:, NCT00122460. Registered 22 Juli 2005,

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Author:Markus HechtORCiDGND, Dennis Hahn, Philipp Wolber, Matthias Günther Hautmann, Dietmar Reichert, Steffi Weniger, Claus Belka, Tobias Bergmann, Thomas Göhler, Manfred WelslauGND, Christina Große-Thie, Orlando Guntinas-LichiusORCiDGND, Jens Müller-von der GrünORCiDGND, Panagiotis BalermpasORCiDGND, Katrin Orlowski, Diethelm Messinger, Karsten G. Stenzel, Rainer FietkauORCiDGND
Parent Title (English):BMC Cancer
Publisher:BioMed Central
Place of publication:London
Document Type:Article
Date of Publication (online):2020/09/29
Date of first Publication:2020/09/29
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/11/05
Issue:Article number: 933
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0