Influence of ridge preservation procedures on extraction socket healing under antiresorptive therapy: An experimental study in rabbits

  • Background: To assess the influence of ridge preservation procedures on the healing of extraction sockets under antiresorptive therapy. Material and Methods: A total of 10 Dutch Belted rabbits were randomly allocated to either the intravenous administration of amino‐bisphosphonate (zoledronic acid) (Za) (n = 5) or a negative control group (no Za [nZa]) (n = 5). At 6 months, the mandibular and maxillary molars were extracted and the four experimental sites randomly allocated to the following subgroups: (a) socket grafting using a collagen‐coated natural bone mineral (BOC) + primary wound closure, (b) coronectomy (CO), or (c) spontaneous healing + primary wound closure (SP). Za medication was continued for another 4 months. Histomorphometrical analyses considered, for example, crestal hard tissue closure of the extraction site (C) and mineralized tissue (MT) formation. Results: Za‐SP was associated with an incomplete median C (31.76% vs 100% in nZa‐SP) and signs of bone arrosion along the confines of the socket. BOC had no major effects on increases in C and MT values in the Za group. CO commonly resulted in an encapsulation and partial replacement resorption of residual roots by MT without any histological signs of osteonecrosis. Conclusions: (a) Za‐SP was commonly associated with a compromised socket healing and signs of osteonecrosis, (b) BOC had no major effect on socket healing in the Za group, and (c) CO at noninfected teeth might be a feasible measure for the prevention of a Za‐related osteonecrosis of the jaw.

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Author:Frank SchwarzORCiDGND, Gordon JohnORCiDGND, Jürgen Becker, Knut Achim Grötz, Robert Alexander SaderORCiDGND, Ilja MihatovicGND
URN:urn:nbn:de:hebis:30:3-564673
DOI:https://doi.org/10.1111/cid.12916
ISSN:1708-8208
ISSN:1523-0899
Parent Title (English):Clinical implant dentistry and related research
Publisher:Wiley-Blackwell
Place of publication:Oxford [u.a.]
Document Type:Article
Language:English
Date of Publication (online):2020/06/15
Date of first Publication:2020/06/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/11/11
Tag:animal experiment; antiresorptive agents; extraction socket healing; histological technic; ridge preservation
Volume:22
Issue:4
Page Number:9
First Page:477
Last Page:485
HeBIS-PPN:477035248
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0